Ke Xu Cytoskeletal Structure in Axons Actin , Spectrin , and Associated Proteins Form a Periodic
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منابع مشابه
Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons.
Actin and spectrin play important roles in neurons, but their organization in axons and dendrites remains unclear. We used stochastic optical reconstruction microscopy to study the organization of actin, spectrin, and associated proteins in neurons. Actin formed ringlike structures that wrapped around the circumference of axons and were evenly spaced along axonal shafts with a periodicity of ~1...
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Superresolution fluorescence microscopy recently revealed a ~190 nm periodic cytoskeleton lattice consisting of actin, spectrin, and other proteins underneath the membrane of cultured hippocampal neurons. Whether the periodic cytoskeleton lattice is a structural feature of all neurons and how it is modified when axons are ensheathed by myelin forming glial cells is not known. Here, STED nanosco...
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9 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 215 No. 1 9–11 www.jcb.org/cgi/doi/10.1083/jcb.201609084 A protein’s location reflects its function. This is especially apparent in neurons because of their complex morphologies and highly specialized membrane domains. For example, the most basic division in neuronal morphology is the distinction between dendrites and axons. A neuron ...
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Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. In the MPS, short actin filaments, capped by actin-capping proteins, form ring-like structures that wrap around the circumference of neurites, and these rings are periodically spaced along the neurite by spectrin tetramers, forming a quasi-1D lattice structure. This 1D MPS structure was init...
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The kinetics of slow axonal transport in newly regenerating axonal sprouts were compared with those in nonelongating axons. The slowly transported cytoskeletal proteins of ventral motor axons were prelabeled by microinjection of 35S-methionine into the spinal cord. Pulse-labeled slow transport "waves" were observed as they progressed from the surviving "parent" axon stumps (located proximal to ...
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